Backgrond: Papillary Thyroid Carcinoma (PTC), unlike other cancers, is completely curable if the treatment begins at early stages of the disease, before any metastasis occurs. One of the common places that the cancer may invade is the neck lymph nodes. On this basis, many surgeons suggest prophylactic central neck lymph nodes dissection in such patients, but others do not agree because of the risks that may exceed the benefits of this approach. Despite the presence of several studies in this regard, the debate is still ongoing. Therefore, the present study was conducted to examine the effect of prophylactic central neck lymph node dissection on preventing recurrence in patients with PTC.Materials & Methods: In the current clinical trial, a total of 122 patients with PTC were enrolled who were categorized in two equal 61-patient groups, with (case) and without (control) prophylactic central neck lymph nodes dissection. Short-term (up to 10 days post-operation) and long-term (six months post-operation) consequences were compared between the two groups. None of the patients had evidences of central cervical lymph node involvement before operation. The results were analyzed using Chi-square and t-test.Results: Both groups were comparable in terms of age (mean, 46.1 years in the case group and 45.8 years in the control group) and sex (10 males in the case group and 11 males in the control group). In the case group, there were 16 patients (26.2%) with pathology-proven central cervical lymph node involvement. Serum calcium level dropped more significantly in the case group immediately after the surgery, but returned to a comparable level with that in the controls at the six-month time-point. Comparison of cases and controls showed no significant difference in terms of vocal cord involvement (4.9% vs.3.3%, respectively; p=0.50), recurrent mass (0% vs.3%, respectively; p=0.49) or new regional lymphadenopathy (1.6% vs.7%, respectively; p=0.37). None of the patients in the study deceased nor had recurrent nerve injury.Conclusion: Prophylactic central cervical lymph node dissection has no significant effect on the occurrence rate of short-term/long-term complications of surgery in patients with PTC.